Anyone transitioned from Acute Rehab to Med Surg??

So I've been working for about three years in various rehab settings. I started out out in an LTC, then to an acute rehab floor in a hospital then to a spinal cord injury unit. I've picked up a decent amount of skills during this time- wound care, IV pumps, Heplocks, PICC lines, tube feedings, trach care and transfusions just to name a few.
Out of sheer curiosity (plus I'm feeling adventurous), I'm considering leaving my comfort zone to explore med-surg and hopefully PICU in the future. However, I'm worried that the transition will be hard to make. I have floated to other units occasionally, and the biggest challenge for me has been juggling six brand new patients that I have never set eyes on before, as opposed to rehab where you're somewhat familiar with all your patients. I also need to brush up on my tele skills. Most importantly how will I know what to do if one of my pt codes?? I haven't had that experience (knock on wood), but how much of this will be covered at unit orientation?
Lastly, how much do your co-workers expect you to know once you hit the floor? Has any one of run into something you had never done before and how did you handle it? Any advice will be greatly appreciated .