what are some significant clinical issues

What are some significant clinical issues
Can you be more specific?

Regarding what exactly? As a student? With patients? In a hospital?

OP (which means, "original poster"), don't bother to finish your sentence if you meant to ask us to answer a homework question for you. While we are more than happy to help students find their ways to answers, we ask that you tell us what you have learned already and how you have tried to learn more before we know the best way to do that.And the answer is not, "Just tell me the answer." That path leads nowhere. So, what can we help you with?