DIGOXIN - conflicting information! (Hypothyroidism)

Sry (crossposting - in med savvy I needed a mod approval?)

So, have a pharm test tomorrow. Studying my drug cards. Have 3 sources: 2010 Davis drug guide, 17th edition Medi Quick Cards by LWW, and 9th Clinical Drug therapy by Abrams.

So: DIGOXIN. I know this drug well... however, I have a questions about HYPOTHYROIDISM.

I'd like an answer before tomorrow's test, but I am 90% certain this will not be a question (but, justincase )

Medi Quick cards say, "Hypothyroid patients may need *larger* doses."

Clinical drug therapy monograph says, "Patients with hypothyroidism are extremely sensitive to cardiac glycosides and may need *lower* doses."

Davis' says: "Use caution in hypothyroid patients."

Hmm... conflicting for sure

Anyone with some additional data?

Thanks Off to study some more. Last test of the semester, and I need a 60% to maintain my "A" This is the LPN to RN transition course. I am mighty proud... or, well, I will be when I get at least a 66%

~ Demy
patients with hypothyroidism are more sensitive to this drug and therefore need a LOWER dose to avoid toxicity

Go by your textbook. this way if it is in the test you are able to use the textbook to show the professor where it says that.

Here is the answer: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1674491/